Thiouracil, propylthiouracil, benzylthiouracil

Pulmonary valve stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27831		 Yoshihara (Controls exposed to MMI), 2021 Pulmonary valve stenosis 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.13 [0.00;3.16] C
excluded (control group) 		1/541   0/23 1 541
ref
S8481
R27765		 Yoshihara (Controls unexposed, sick), 2021 Pulmonary valve stenosis 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.88 [0.05;14.07] C 1/541   1/475 2 541
ref
S3359
R6111		 Howley, 2017 Pulmonary valve stenosis 1st trimester case control unexposed, disease free Adjustment: No 0.71 [0.09;5.59] C 1/11   1,514/12,339 1,515 11
ref
Total 2 studies 0.77 [0.15;4.01] 1,517 552
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 0.88[0.05; 14.07]254135%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Howley, 2017Howley, 2017 0.71[0.09; 5.59]1,5151165%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.77[0.15; 4.01]1,5175520.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.05; 14.07]2541 -NAYoshihara (Controls unexposed, sick), 2021 1 case control studiescase control studies 0.71[0.09; 5.59]1,51511 -NAHowley, 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.71[0.09; 5.59]1,51511 -NAHowley, 2017 1 unexposed, sickunexposed, sick 0.88[0.05; 14.07]2541 -NAYoshihara (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 0.77[0.15; 4.01]1,5175520%NAYoshihara (Controls unexposed, sick), 2021 Howley, 2017 2 All studiesAll studies 0.77[0.15; 4.01]1,5175520%NAYoshihara (Controls unexposed, sick), 2021 Howley, 2017 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.71[0.09; 5.59]1,51511 -NAHowley, 2017 1 unexposed, sick controlsunexposed, sick controls 0.88[0.05; 14.07]2541 -NAYoshihara (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.13[0.00; 3.16]1541 -NAYoshihara (Controls exposed to MMI), 2021 10.510.01.0