Thiouracil, propylthiouracil, benzylthiouracil

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27836		 Yoshihara (Controls exposed to MMI), 2021 Polydactyly 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.13 [0.00;3.16] C
excluded (control group) 		1/541   0/23 1 541
ref
S8481
R27770		 Yoshihara (Controls unexposed, sick), 2021 Polydactyly 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.64 [0.11;64.93] C 1/541   0/475 1 541
ref
Total 1 studies 2.64 [0.11;64.93] 1 541
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 2.64[0.11; 64.93]15410%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.64[0.11; 64.93]1541 -NAYoshihara (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.64[0.11; 64.93]1541 -NAYoshihara (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 2.64[0.11; 64.93]1541 -NAYoshihara (Controls unexposed, sick), 2021 1 All studiesAll studies 2.64[0.11; 64.93]1541 -NAYoshihara (Controls unexposed, sick), 2021 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.64[0.11; 64.93]1541 -NAYoshihara (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.13[0.00; 3.16]1541 -NAYoshihara (Controls exposed to MMI), 2021 10.510.01.0