Thiouracil, propylthiouracil, benzylthiouracil

Hyperthyroidism / Thyrotoxicosis (fetal/neonatal)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3422
R10983
Hawken (control exposed to MMI), 2016 Neonatal hyperthyroidism 2nd trimester retrospective cohort exposed to other treatment, sick Adjustment: No 1.54 [0.06;41.08] C 1/22   0/11 1 22
ref
S3456
R6575
Dwarakanath (control exposed to MMI), 1999 Clinical thyroid dysfunction (neonatal thyrotoxicosis) throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
S3439
R6386
Davis, 1989 Neonatal Thyrotoxicosis during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.45 [0.02;11.98] C 1/52   0/8 1 52
ref
Total 3 studies 0.87 [0.12;6.53] 2 81
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hawken (control exposed to MMI), 2016Hawken, 2016 1 1.54[0.06; 41.08]12238%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: lowROB mesure: criticalROB reporting: unclear Dwarakanath (control exposed to MMI), 1999Dwarakanath, 1999 2 1.00[0.02; 58.44]0725%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Davis, 1989Davis, 1989 0.45[0.02; 11.98]15238%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: unclear Total (3 studies) I2 = 0% 0.87[0.12; 6.53]2810.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to MMI; 2: control exposed to MMI;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.12; 6.53]2810%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Davis, 1989 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.45[0.02; 11.98]152 -NADavis, 1989 1 exposed to other treatment, sickexposed to other treatment, sick 1.30[0.10; 16.71]1290%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 2 Tags Adjustment   - No  - No 0.87[0.12; 6.53]2810%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Davis, 1989 3 All studiesAll studies 0.87[0.12; 6.53]2810%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Davis, 1989 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.02; 11.98]152 -NADavis, 1989 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.30[0.10; 16.71]1290%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 20.510.01.0