Thiouracil, propylthiouracil, benzylthiouracil

Hypothyroidism (fetal/neonatal)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3422
R10982
Hawken (control exposed to MMI), 2016 Neonatal hypothyroidism 2nd trimester retrospective cohort exposed to other treatment, sick Adjustment: No 1.54 [0.06;41.08] C 1/22   0/11 1 22
ref
S3456
R6573
Dwarakanath (control exposed to MMI), 1999 Clinical thyroid dysfunction (Hypothyroidism) throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
S3393
R6589
Wing (control exposed to MMI), 1994 Congenital hypothyroidism during pregnancy (anytime or not specified) cohort exposed to other treatment, sick excluded Adjustment: No 1.09 [0.04;27.44] C
excluded (control group)
1/99   0/36 1 99
ref
S3394
R6590
Wing (control unexposed, sick), 1994 Congenital hypothyroidism during pregnancy (anytime or not specified) cohort unexposed, sick Adjustment: No 1.31 [0.05;32.76] C 1/99   0/43 1 99
ref
S3439
R6387
Davis, 1989 Neonatal Hypothyroidism during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.45 [0.02;11.98] C 1/52   0/8 1 52
ref
Total 4 studies 0.97 [0.18;5.39] 3 180
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hawken (control exposed to MMI), 2016Hawken, 2016 1 1.54[0.06; 41.08]12227%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: lowROB mesure: criticalROB reporting: unclear Dwarakanath (control exposed to MMI), 1999Dwarakanath, 1999 2 1.00[0.02; 58.44]0718%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Wing (control unexposed, sick), 1994Wing, 1994 3 1.31[0.05; 32.76]19928%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Davis, 1989Davis, 1989 0.45[0.02; 11.98]15227%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: unclear Total (4 studies) I2 = 0% 0.97[0.18; 5.39]31800.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to MMI; 2: control exposed to MMI; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.97[0.18; 5.39]31800%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Wing (control unexposed, sick), 1994 Davis, 1989 4 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.77[0.08; 7.72]21510%NAWing (control unexposed, sick), 1994 Davis, 1989 2 exposed to other treatment, sickexposed to other treatment, sick 1.30[0.10; 16.71]1290%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 2 Tags Adjustment   - No  - No 0.97[0.18; 5.39]31800%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Wing (control unexposed, sick), 1994 Davis, 1989 4 All studiesAll studies 0.97[0.18; 5.39]31800%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Wing (control unexposed, sick), 1994 Davis, 1989 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.94.92.4910.000Hawken (control exposed to MMI), 2016Dwarakanath (control exposed to MMI), 1999Wing (control unexposed, sick), 1994Davis, 1989

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 3393

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.77[0.08; 7.72]21510%NAWing (control unexposed, sick), 1994 Davis, 1989 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.21[0.16; 8.99]21280%NAHawken (control exposed to MMI), 2016 Dwarakanath (control exposed to MMI), 1999 Wing (control exposed to MMI), 1994 30.510.01.0