Thiouracil, propylthiouracil, benzylthiouracil

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3564
R7114		 Gianetti (control exposed to MMI), 2015 Perinatal death at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 7.34 [0.29;183.14] C
excluded (control group) 		1/52   0/124 1 52
ref
S3565
R7125		 Gianetti (control unexposed, sick), 2015 Perinatal death throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 12.03 [0.48;299.72] C 1/52   0/203 1 52
ref
S3355
R6056		 Yoshihara (control exposed to MMI), 2012 Perinatal loss 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.27 [0.40;4.00] C
excluded (control group) 		7/1,578   5/1,426 12 1,578
ref
S3354
R6013		 Yoshihara (control unexposed, sick), 2012 Perinatal loss 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.83 [0.32;2.15] C 7/1,578   11/2,065 18 1,578
ref
Total 2 studies 2.00 [0.17;23.33] 19 1,630
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 12.03[0.48; 299.72]15233%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: critical Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 0.83[0.32; 2.15]181,57867%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 59% 2.00[0.17; 23.33]191,6300.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.00[0.17; 23.33]191,63059%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.00[0.17; 23.33]191,63059%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 2.00[0.17; 23.33]191,63059%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 2.00[0.17; 23.33]191,63059%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 20.250.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.00[0.17; 23.33]191,63059%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.56[0.51; 4.77]131,6302%NAGianetti (control exposed to MMI), 2015 Yoshihara (control exposed to MMI), 2012 20.510.01.0