Thiouracil, propylthiouracil, benzylthiouracil

Neonatal hyperthyrotropinemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3564
R7110		 Gianetti (control exposed to MMI), 2015 Transient hyperthyropinemia (elevated serum TSH) at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.61 [0.26;9.95] C
excluded (control group) 		2/52   3/124 5 52
ref
S3565
R7121		 Gianetti (control unexposed, sick), 2015 Transient hyperthyropinemia (elevated serum TSH) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 20.45 [0.97;432.89] C 2/52   0/203 2 52
ref
S3469
R6638		 Momotani (control exposed to MMI), 1997 Fetal TSH levels above the normal range throughout pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 1.60 [0.48;5.30] C 7/34   6/43 13 34
ref
Total 2 studies 3.82 [0.36;40.91] 15 86
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 20.45[0.97; 432.89]25234%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Momotani (control exposed to MMI), 1997Momotani, 1997 2 1.60[0.48; 5.30]133466%ROB confusion: criticalROB selection: unclearROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 57% 3.82[0.36; 40.91]15860.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control exposed to MMI;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.82[0.36; 40.91]158657%NAGianetti (control unexposed, sick), 2015 Momotani (control exposed to MMI), 1997 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 20.45[0.97; 432.89]252 -NAGianetti (control unexposed, sick), 2015 1 exposed to other treatment, sickexposed to other treatment, sick 1.60[0.48; 5.30]1334 -NAMomotani (control exposed to MMI), 1997 1 Tags Adjustment   - No  - No 3.82[0.36; 40.91]158657%NAGianetti (control unexposed, sick), 2015 Momotani (control exposed to MMI), 1997 2 All studiesAll studies 3.82[0.36; 40.91]158657%NAGianetti (control unexposed, sick), 2015 Momotani (control exposed to MMI), 1997 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale20.45[0.97; 432.89]252 -NAGianetti (control unexposed, sick), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.60[0.48; 5.30]1334 -NAMomotani (control exposed to MMI), 1997 10.510.01.0