Thiouracil, propylthiouracil, benzylthiouracil

Eye, ear, face and neck malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3366
R6153		 Seo (control exposed to MMI), 2018 Eye, ear, face, and neck (Q10 to Q18) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.16 [0.41;3.24] C
excluded (control group) 		41/9,930   4/1,120 45 9,930
ref
S3367
R6165		 Seo (control unexposed, NOS), 2018 Eye, ear, face, and neck (Q10 to Q18) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.21 [0.89;1.64] 41/9,930   9,443/2,872,109 9,484 9,930
ref
Total 1 studies 1.21 [0.89;1.64] 9,484 9,930
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo (control unexposed, NOS), 2018Seo, 2018 1 1.21[0.89; 1.64]9,4849,9300%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.89; 1.64]9,4849,930 -NASeo (control unexposed, NOS), 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.21[0.89; 1.64]9,4849,930 -NASeo (control unexposed, NOS), 2018 1 Tags Adjustment   - Yes  - Yes 1.21[0.89; 1.64]9,4849,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.21[0.89; 1.64]9,4849,930 -NASeo (control unexposed, NOS), 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3366

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.21[0.89; 1.64]9,4849,930 -NASeo (control unexposed, NOS), 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.16[0.41; 3.24]459,930 -NASeo (control exposed to MMI), 2018 10.510.01.0