Thiouracil, propylthiouracil, benzylthiouracil

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3366
R6152		 Seo (control exposed to MMI), 2018 Nervous system (Q00–Q07) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.35 [0.15;0.83] C
excluded (control group) 		22/9,930   7/1,120 29 9,930
ref
S3367
R6164		 Seo (control unexposed, NOS), 2018 Nervous system (Q00–Q07) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.05 [0.69;1.60] 22/9,930   5,843/2,872,109 5,865 9,930
ref
S3340
R5752		 Andersen 2017 (control exposed to MMI/CMZ), 2017 Nervous system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 2.24 [0.09;55.29] C
excluded (control group) 		1/218   0/162 1 218
ref
S3339
R5735		 Andersen 2017 (control unexposed, disease free), 2017 Nervous system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 3.08 [0.43;22.02] C
excluded (control group) 		1/218   1,018/682,343 1,019 218
ref
S3338
R5718		 Andersen 2017 (control unexposed, sick), 2017 Nervous system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 3.57 [0.32;39.53] C 1/218   2/1,551 3 218
ref
Total 2 studies 1.09 [0.72;1.65] 5,868 10,148
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo (control unexposed, NOS), 2018Seo, 2018 1 1.05[0.69; 1.60]5,8659,93097%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 3.57[0.32; 39.53]32183%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.09[0.72; 1.65]5,86810,1480.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, NOS; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.72; 1.65]5,86810,1480%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.05[0.69; 1.60]5,8659,930 -NASeo (control unexposed, NOS), 2018 1 unexposed, sickunexposed, sick 3.57[0.32; 39.53]3218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 3.57[0.32; 39.53]3218 -NAAndersen 2017 (control unexposed, sick), 2017 1   - Yes  - Yes 1.05[0.69; 1.60]5,8659,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.09[0.72; 1.65]5,86810,1480%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3340, 3339, 3366

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.64; 2.09]6,88410,1489%NASeo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 3.57[0.32; 39.53]3218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.45[0.13; 1.56]3010,14816%NASeo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 20.510.01.0