Thiouracil, propylthiouracil, benzylthiouracil

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3448
R6453
Andersen 2019 (control exposed to MMI/CMZ), 2019 Eye (Q10-15) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.12 [0.01;2.06] C
excluded (control group)
0/889   7/1,574 7 889
ref
S3449
R6468
Andersen 2019 (control unexposed, disease free), 2019 Eye (Q10-15) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 0.26 [0.02;4.20] C 0/889   2,480/1,159,181 2,480 889
ref
S3340
R5753
Andersen 2017 (control exposed to MMI/CMZ), 2017 Eye early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.15 [0.01;3.08] C
excluded (control group)
0/218   2/162 2 218
ref
S3339
R5736
Andersen 2017 (control unexposed, disease free), 2017 Eye early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.50 [0.03;7.99] C
excluded (control group)
0/218   3,134/682,343 3,134 218
ref
S3338
R5719
Andersen 2017 (control unexposed, sick), 2017 Eye early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.79 [0.04;14.73] C 0/218   4/1,551 4 218
ref
S8718
R29458
Korelitz (control exposed to MMI), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.12 [0.01;1.89] C
excluded (control group)
1/915   1/108 2 915
ref
S3387
R6307
Korelitz (control exposed to MMI), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.12 [0.01;1.89] C
excluded (control group)
1/915   1/108 2 915
ref
S3388
R6315
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.45 [0.06;3.20] C
excluded (control group)
1/915   1,540/634,858 1,541 915
ref
S3389
R6323
Korelitz (control unexposed, sick), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.44 [0.06;3.53] C
excluded (exposition period)
1/915   8/3,236 9 915
ref
Total 2 studies 0.44 [0.06;3.31] 2,484 1,107
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2019 (control unexposed, disease free), 2019Andersen 2019, 2019 1 0.26[0.02; 4.20]2,48088953%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 0.79[0.04; 14.73]421847%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.44[0.06; 3.31]2,4841,1070.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.44[0.06; 3.31]2,4841,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.26[0.02; 4.20]2,480889 -NAAndersen 2019 (control unexposed, disease free), 2019 1 unexposed, sickunexposed, sick 0.79[0.04; 14.73]4218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 0.44[0.06; 3.31]2,4841,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 All studiesAll studies 0.44[0.06; 3.31]2,4841,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8718, 3387, 3388, 3340, 3339, 3448

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.36[0.05; 2.57]5,6141,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 0.79[0.04; 14.73]4218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.13[0.02; 1.05]91,1070%NAAndersen 2019 (control exposed to MMI/CMZ), 2019 Andersen 2017 (control exposed to MMI/CMZ), 2017 20.510.01.0