Thiouracil, propylthiouracil, benzylthiouracil

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3448
R6456		 Andersen 2019 (control exposed to MMI/CMZ), 2019 Circulatory system (Q20-28) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.72 [0.40;1.30] C
excluded (control group) 		16/889   39/1,574 55 889
ref
S3449
R6471		 Andersen 2019 (control unexposed, disease free), 2019 Circulatory system (Q20-28) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 1.38 [0.84;2.26] C 16/889   15,195/1,159,181 15,211 889
ref
S3366
R6154		 Seo (control exposed to MMI), 2018 Circulatory system (Q20–Q28) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.62 [0.44;0.88] C
excluded (control group) 		230/9,930   41/1,120 271 9,930
ref
S3367
R6166		 Seo (control unexposed, NOS), 2018 Circulatory system (Q20–Q28) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.02 [0.90;1.17] 230/9,930   62,086/2,872,109 62,316 9,930
ref
S3340
R5756		 Andersen 2017 (control exposed to MMI/CMZ), 2017 Circulatory systems early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.36 [0.09;1.47] C
excluded (control group) 		3/218   6/162 9 218
ref
S3339
R5739		 Andersen 2017 (control unexposed, disease free), 2017 Circulatory systems early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.72 [0.23;2.25] C
excluded (control group) 		3/218   12,981/682,343 12,984 218
ref
S3338
R5722		 Andersen 2017 (control unexposed, sick), 2017 Circulatory systems early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.56 [0.17;1.82] C 3/218   38/1,551 41 218
ref
Total 3 studies 1.05 [0.84;1.31] 77,568 11,037
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2019 (control unexposed, disease free), 2019Andersen 2019, 2019 1 1.38[0.84; 2.26]15,21188917%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.02[0.90; 1.17]62,3169,93079%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 0.56[0.17; 1.82]412183%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 17% 1.05[0.84; 1.31]77,56811,0370.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.84; 1.31]77,56811,03717%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.08[0.86; 1.35]77,52710,81925%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 0.56[0.17; 1.82]41218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.03[0.45; 2.37]15,2521,10748%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.02[0.89; 1.16]62,3169,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.05[0.84; 1.31]77,56811,03717%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3340, 3339, 3366, 3448

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.91; 1.17]90,51111,0370%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 0.56[0.17; 1.82]41218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.63[0.47; 0.84]33511,0370%NAAndersen 2019 (control exposed to MMI/CMZ), 2019 Seo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 30.510.01.0