Thiouracil, propylthiouracil, benzylthiouracil

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3448
R6457
Andersen 2019 (control exposed to MMI/CMZ), 2019 Respiratory system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.92 [0.46;1.86] C
excluded (control group)
12/889   23/1,574 35 889
ref
S3449
R6472
Andersen 2019 (control unexposed, disease free), 2019 Respiratory system early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 1.63 [0.92;2.89] C 12/889   9,636/1,159,181 9,648 889
ref
S3366
R6155
Seo (control exposed to MMI), 2018 Respiratory system (Q30–Q34) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.90 [0.27;3.00] C
excluded (control group)
24/9,930   3/1,120 27 9,930
ref
S3367
R6167
Seo (control unexposed, NOS), 2018 Respiratory system (Q30–Q34) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.09 [0.73;1.63] 24/9,930   6,317/2,872,109 6,341 9,930
ref
S3340
R5757
Andersen 2017 (control exposed to MMI/CMZ), 2017 Respiratory system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.25 [0.01;6.08] C
excluded (control group)
0/218   1/162 1 218
ref
S3339
R5740
Andersen 2017 (control unexposed, disease free), 2017 Respiratory system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.20 [0.01;3.14] C
excluded (control group)
0/218   7,927/682,343 7,927 218
ref
S3338
R5723
Andersen 2017 (control unexposed, sick), 2017 Respiratory system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.19 [0.01;3.17] C 0/218   18/1,551 18 218
ref
S8718
R29461
Korelitz (control exposed to MMI), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.30 [0.07;23.68] C
excluded (control group)
5/915   0/108 5 915
ref
S3387
R6310
Korelitz (control exposed to MMI), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.30 [0.07;23.68] C
excluded (control group)
5/915   0/108 5 915
ref
S3388
R6318
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 2.03 [0.84;4.89] C
excluded (control group)
5/915   1,714/634,858 1,719 915
ref
S3389
R6326
Korelitz (control unexposed, sick), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 2.22 [0.72;6.79] C
excluded (exposition period)
5/915   8/3,236 13 915
ref
Total 3 studies 1.22 [0.76;1.96] 16,007 11,037
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2019 (control unexposed, disease free), 2019Andersen 2019, 2019 1 1.63[0.92; 2.89]9,64888940%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.09[0.73; 1.63]6,3419,93057%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 0.19[0.01; 3.17]182183%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 33% 1.22[0.76; 1.96]16,00711,0370.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.76; 1.96]16,00711,03733%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[0.86; 1.85]15,98910,81922%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 0.19[0.01; 3.17]18218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 0.88[0.13; 5.92]9,6661,10754%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.09[0.73; 1.63]6,3419,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.22[0.76; 1.96]16,00711,03733%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8718, 3387, 3388, 3340, 3339, 3366, 3448

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.76; 1.96]23,91611,03733%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls Out of scale0.19[0.01; 3.17]18218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.48; 1.59]6311,0370%NAAndersen 2019 (control exposed to MMI/CMZ), 2019 Seo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 30.510.01.0