Thiouracil, propylthiouracil, benzylthiouracil

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3448
R6460
Andersen 2019 (control exposed to MMI/CMZ), 2019 Urinary system (Q60-64) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.03 [0.41;2.63] C
excluded (control group)
7/889   12/1,574 19 889
ref
S3449
R6475
Andersen 2019 (control unexposed, disease free), 2019 Urinary system (Q60-64) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 2.22 [1.06;4.68] C 7/889   4,125/1,159,181 4,132 889
ref
S3366
R6159
Seo (control exposed to MMI), 2018 Urinary system (Q60–Q64) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.13 [0.49;2.62] C
excluded (control group)
60/9,930   6/1,120 66 9,930
ref
S3367
R6171
Seo (control unexposed, NOS), 2018 Urinary system (Q60–Q64) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.28 [0.99;1.65] 60/9,930   13,494/2,872,109 13,554 9,930
ref
S3340
R5760
Andersen 2017 (control exposed to MMI/CMZ), 2017 Urinary system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 2.25 [0.23;21.80] C
excluded (control group)
3/218   1/162 4 218
ref
S3339
R5743
Andersen 2017 (control unexposed, disease free), 2017 Urinary system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 3.33 [1.07;10.42] C
excluded (control group)
3/218   2,846/682,343 2,849 218
ref
S3338
R5726
Andersen 2017 (control unexposed, sick), 2017 Urinary system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 3.08 [0.79;11.99] C 3/218   7/1,551 10 218
ref
S8718
R29463
Korelitz (control exposed to MMI), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.78 [0.10;31.33] C
excluded (control group)
7/915   0/108 7 915
ref
S3387
R6312
Korelitz (control exposed to MMI), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.78 [0.10;31.33] C
excluded (control group)
7/915   0/108 7 915
ref
S3388
R6320
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.75 [0.83;3.69] C
excluded (control group)
7/915   2,780/634,858 2,787 915
ref
S3389
R6328
Korelitz (control unexposed, sick), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 1.55 [0.64;3.78] C
excluded (exposition period)
7/915   16/3,236 23 915
ref
Total 3 studies 1.63 [1.01;2.62] 17,696 11,037
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2019 (control unexposed, disease free), 2019Andersen 2019, 2019 1 2.22[1.06; 4.68]4,13288927%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.28[0.99; 1.65]13,5549,93063%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 3.08[0.79; 11.99]1021811%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 38% 1.63[1.01; 2.62]17,69611,0370.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[1.01; 2.62]17,69611,03738%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.50[0.92; 2.46]17,68610,81947%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 3.08[0.79; 11.99]10218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 2.40[1.25; 4.60]4,1421,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.28[0.99; 1.65]13,5549,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.63[1.01; 2.62]17,69611,03738%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8718, 3387, 3388, 3340, 3339, 3366, 3448

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.76[1.02; 3.03]20,53511,03752%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 3.08[0.79; 11.99]10218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.14[0.62; 2.09]8911,0370%NAAndersen 2019 (control exposed to MMI/CMZ), 2019 Seo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 30.510.01.0