Thiouracil, propylthiouracil, benzylthiouracil

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3448
R6459
Andersen 2019 (control exposed to MMI/CMZ), 2019 Genital organs (Q50-56) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.06 [0.46;2.44] C
excluded (control group)
9/889   15/1,574 24 889
ref
S3449
R6474
Andersen 2019 (control unexposed, disease free), 2019 Genital organs (Q50-56) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 0.96 [0.50;1.86] C 9/889   12,182/1,159,181 12,191 889
ref
S3366
R6158
Seo (control exposed to MMI), 2018 Genital organs (Q50–Q56) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.98 [0.45;2.15] C
excluded (control group)
61/9,930   7/1,120 68 9,930
ref
S3367
R6170
Seo (control unexposed, NOS), 2018 Genital organs (Q50–Q56) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.29 [1.00;1.66] 61/9,930   13,532/2,872,109 13,593 9,930
ref
S3340
R5759
Andersen 2017 (control exposed to MMI/CMZ), 2017 Genital organs early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.29 [0.06;1.52] C
excluded (control group)
2/218   5/162 7 218
ref
S3339
R5742
Andersen 2017 (control unexposed, disease free), 2017 Genital organs early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.66 [0.16;2.66] C
excluded (control group)
2/218   9,415/682,343 9,417 218
ref
S3338
R5725
Andersen 2017 (control unexposed, sick), 2017 Genital organs early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.57 [0.13;2.40] C 2/218   25/1,551 27 218
ref
S8718
R29462
Korelitz (control exposed to MMI), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 2.50 [0.15;42.90] C
excluded (control group)
10/915   0/108 10 915
ref
S3387
R6311
Korelitz (control exposed to MMI), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 2.50 [0.15;42.90] C
excluded (control group)
10/915   0/108 10 915
ref
S3388
R6319
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.13 [0.60;2.10] C
excluded (control group)
10/915   6,161/634,858 6,171 915
ref
S3389
R6327
Korelitz (control unexposed, sick), 2013 Congenital anomalies of genital organs 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 1.18 [0.58;2.42] C
excluded (exposition period)
10/915   30/3,236 40 915
ref
Total 3 studies 1.22 [0.96;1.54] 25,811 11,037
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2019 (control unexposed, disease free), 2019Andersen 2019, 2019 1 0.96[0.50; 1.86]12,19188913%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.29[1.00; 1.66]13,5939,93085%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 0.57[0.13; 2.40]272183%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.22[0.96; 1.54]25,81111,0370.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.96; 1.54]25,81111,0370%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.24[0.98; 1.57]25,78410,8190%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 0.57[0.13; 2.40]27218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 0.88[0.48; 1.60]12,2181,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.29[1.00; 1.66]13,5939,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.22[0.96; 1.54]25,81111,0370%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8718, 3387, 3388, 3340, 3339, 3366, 3448

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.97; 1.54]35,20111,0370%NAAndersen 2019 (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 0.57[0.13; 2.40]27218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.89[0.52; 1.53]9911,0370%NAAndersen 2019 (control exposed to MMI/CMZ), 2019 Seo (control exposed to MMI), 2018 Andersen 2017 (control exposed to MMI/CMZ), 2017 30.510.01.0