Thiouracil, propylthiouracil, benzylthiouracil

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3564
R7113		 Gianetti (control exposed to MMI), 2015 Chromosomal abnormalities at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 12.47 [0.59;264.54] C
excluded (control group) 		2/52   0/124 2 52
ref
S3565
R7124		 Gianetti (control unexposed, sick), 2015 Chromosomal abnormalities throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 4.02 [0.55;29.24] C 2/52   2/203 4 52
ref
Total 1 studies 4.02 [0.55;29.24] 4 52
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 4.02[0.55; 29.24]4520%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.02[0.55; 29.24]452 -NAGianetti (control unexposed, sick), 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.02[0.55; 29.24]452 -NAGianetti (control unexposed, sick), 2015 1 Tags Adjustment   - No  - No 4.02[0.55; 29.24]452 -NAGianetti (control unexposed, sick), 2015 1 All studiesAll studies 4.02[0.55; 29.24]452 -NAGianetti (control unexposed, sick), 2015 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 4.02[0.55; 29.24]452 -NAGianetti (control unexposed, sick), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale12.47[0.59; 264.54]252 -NAGianetti (control exposed to MMI), 2015 10.510.01.0