Thiouracil, propylthiouracil, benzylthiouracil

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3441
R6396		 Zhang, 2016 Abortion during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.66 [0.14;3.10] C 5/43   3/18 8 43
ref
S3564
R7105		 Gianetti (control exposed to MMI), 2015 Miscarriage (NOS) and voluntary abortions at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.84 [0.28;2.45] C
excluded (control group) 		5/52   14/124 19 52
ref
S3565
R7116		 Gianetti (control unexposed, sick), 2015 Miscarriage (NOS) and voluntary abortions throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 1.69 [0.57;5.04] C 5/52   12/203 17 52
ref
Total 2 studies 1.24 [0.51;3.02] 25 95
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhang, 2016Zhang, 2016 0.66[0.14; 3.10]84333%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 1.69[0.57; 5.04]175267%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: critical Total (2 studies) I2 = 0% 1.24[0.51; 3.02]25950.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.24[0.51; 3.02]25950%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.24[0.51; 3.02]25950%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 Tags Adjustment   - No  - No 1.24[0.51; 3.02]25950%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 All studiesAll studies 1.24[0.51; 3.02]25950%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.24[0.51; 3.02]25950%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.84[0.28; 2.45]1952 -NAGianetti (control exposed to MMI), 2015 10.510.01.0