Thiouracil, propylthiouracil, benzylthiouracil

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3564
R7104		 Gianetti (control exposed to MMI), 2015 Voluntary abortions at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.20 [0.11;13.49] C
excluded (control group) 		1/52   2/124 3 52
ref
S3565
R7115		 Gianetti (control unexposed, sick), 2015 Voluntary abortions throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 3.96 [0.24;64.41] C 1/52   1/203 2 52
ref
S3355
R6058		 Yoshihara (control exposed to MMI), 2012 Abortion 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.39 [0.20;0.74] C
excluded (control group) 		13/1,578   30/1,426 43 1,578
ref
S3354
R6015		 Yoshihara (control unexposed, sick), 2012 Abortion 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.31 [0.61;2.84] C 13/1,578   13/2,065 26 1,578
ref
S3374
R6201		 Rosenfeld, 2009 ETOP (Elective termination of pregnancy) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.14 [0.40;3.26] C 4/115   35/1,141 39 115
ref
Total 3 studies 1.32 [0.72;2.42] 67 1,745
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 3.96[0.24; 64.41]2525%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: critical Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 1.31[0.61; 2.84]261,57862%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Rosenfeld, 2009Rosenfeld, 2009 1.14[0.40; 3.26]3911533%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.32[0.72; 2.42]671,7450.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.32[0.72; 2.42]671,7450%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 Rosenfeld, 2009 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.14[0.40; 3.26]39115 -NARosenfeld, 2009 1 unexposed, sickunexposed, sick 1.42[0.67; 2.98]281,6300%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 1.32[0.72; 2.42]671,7450%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 Rosenfeld, 2009 3 All studiesAll studies 1.32[0.72; 2.42]671,7450%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 Rosenfeld, 2009 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.14[0.40; 3.26]39115 -NARosenfeld, 2009 1 unexposed, sick controlsunexposed, sick controls 1.42[0.67; 2.98]281,6300%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.42[0.22; 0.79]461,6300%NAGianetti (control exposed to MMI), 2015 Yoshihara (control exposed to MMI), 2012 20.510.01.0