Thiouracil, propylthiouracil, benzylthiouracil

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3441
R6399
Zhang, 2016 Preterm birth (≥28 but <37 weeks) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.60 [0.09;3.94] C 3/43   2/18 5 43
ref
S3564
R7106
Gianetti (control exposed to MMI), 2015 Preterm at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.79 [0.08;7.78] C
excluded (control group)
1/52   3/124 4 52
ref
S3565
R7117
Gianetti (control unexposed, sick), 2015 Preterm throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 0.38 [0.05;3.03] C 1/52   10/203 11 52
ref
S3346
R5819
Chen (Control exposed to MMI), 2011 Preterm birth, birth >24 and <37 weeks of gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.55 [0.26;1.17] C
excluded (control group)
45/630   9/73 54 630
ref
S3347
R5823
Chen (control unexposed, disease free), 2011 Preterm birth, birth >24 and <37 weeks of gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.09 [0.80;1.48] C
excluded (control group)
45/630   934/14,150 979 630
ref
S3348
R5827
Chen (control unexposed, sick), 2011 Preterm birth, birth >24 and <37 weeks of gestation during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.92 [0.66;1.31] 45/630   162/2,127 207 630
ref
S3374
R6205
Rosenfeld, 2009 Preterm delivery (<37 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 1.84 [0.91;3.72] C 10/100   58/1,018 68 100
ref
S3456
R6571
Dwarakanath (control exposed to MMI), 1999 Preterm labour throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
Total 5 studies 1.03 [0.73;1.46] 291 832
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhang, 2016Zhang, 2016 0.60[0.09; 3.94]5433%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 0.38[0.05; 3.03]11523%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Chen (control unexposed, sick), 2011Chen, 2011 2 0.92[0.66; 1.31]20763071%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Rosenfeld, 2009Rosenfeld, 2009 1.84[0.91; 3.72]6810022%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Dwarakanath (control exposed to MMI), 1999Dwarakanath, 1999 3 1.00[0.02; 58.44]071%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (5 studies) I2 = 5% 1.03[0.73; 1.46]2918320.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control exposed to MMI;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.73; 1.46]2918325%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 Rosenfeld, 2009 Dwarakanath (control exposed to MMI), 1999 5 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.84[0.91; 3.72]68100 -NARosenfeld, 2009 1 unexposed, sickunexposed, sick 0.89[0.64; 1.24]2237250%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 3 exposed to other treatment, sickexposed to other treatment, sick 1.00[0.02; 58.44]-7 -NADwarakanath (control exposed to MMI), 1999 1 Tags Adjustment   - No  - No 1.39[0.75; 2.59]842020%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 Rosenfeld, 2009 Dwarakanath (control exposed to MMI), 1999 4   - Yes  - Yes 0.92[0.65; 1.30]207630 -NAChen (control unexposed, sick), 2011 1 All studiesAll studies 1.03[0.73; 1.46]2918325%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 Rosenfeld, 2009 Dwarakanath (control exposed to MMI), 1999 50.15.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.94.92.4910.000Zhang, 2016Gianetti (control unexposed, sick), 2015Chen (control unexposed, sick), 2011Rosenfeld, 2009Dwarakanath (control exposed to MMI), 1999

Asymetry test p-value = 0.8422 (by Egger's regression)

slope=0.0577 (0.2727); intercept=-0.1727 (0.7963); t=0.2169; p=0.8422

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 3346, 3347, 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[0.80; 2.06]1,04773044%NAChen (control unexposed, disease free), 2011 Rosenfeld, 2009 2 unexposed, sick controlsunexposed, sick controls 0.89[0.64; 1.24]2237250%NAZhang, 2016 Gianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.58[0.28; 1.18]586890%NAGianetti (control exposed to MMI), 2015 Chen (Control exposed to MMI), 2011 Dwarakanath (control exposed to MMI), 1999 30.510.01.0