Thiouracil, propylthiouracil, benzylthiouracil

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3346
R5818
Chen (Control exposed to MMI), 2011 Low birth weight < 2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.65 [0.31;1.39] C
excluded (control group)
53/630   9/73 62 630
ref
S3347
R5822
Chen (control unexposed, disease free), 2011 Low birth weight < 2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.70 [1.27;2.28] C
excluded (control group)
53/630   725/14,150 778 630
ref
S3348
R5826
Chen (control unexposed, sick), 2011 Low birth weight < 2500 g during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.40 [1.00;1.96] 53/630   129/2,127 182 630
ref
S3456
R6570
Dwarakanath (control exposed to MMI), 1999 Low birth weight throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 2.40 [0.16;34.93] C 2/7   1/7 3 7
ref
Total 2 studies 1.41 [1.01;1.97] 185 637
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chen (control unexposed, sick), 2011Chen, 2011 1 1.40[1.00; 1.96]18263098%ROB confusion: seriousROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Dwarakanath (control exposed to MMI), 1999Dwarakanath, 1999 2 2.40[0.16; 34.93]372%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (2 studies) I2 = 0% 1.41[1.01; 1.97]1856370.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control exposed to MMI;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.41[1.01; 1.97]1856370%NAChen (control unexposed, sick), 2011 Dwarakanath (control exposed to MMI), 1999 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.40[1.00; 1.96]182630 -NAChen (control unexposed, sick), 2011 1 exposed to other treatment, sickexposed to other treatment, sick 2.40[0.16; 34.93]37 -NADwarakanath (control exposed to MMI), 1999 1 Tags Adjustment   - No  - No 2.40[0.16; 34.93]37 -NADwarakanath (control exposed to MMI), 1999 1   - Yes  - Yes 1.40[1.00; 1.96]182630 -NAChen (control unexposed, sick), 2011 1 All studiesAll studies 1.41[1.01; 1.97]1856370%NAChen (control unexposed, sick), 2011 Dwarakanath (control exposed to MMI), 1999 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3346, 3347

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.70[1.27; 2.28]778630 -NAChen (control unexposed, disease free), 2011 1 unexposed, sick controlsunexposed, sick controls 1.40[1.00; 1.96]182630 -NAChen (control unexposed, sick), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.72[0.35; 1.48]656370%NAChen (Control exposed to MMI), 2011 Dwarakanath (control exposed to MMI), 1999 20.510.01.0