Sumatriptan

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3581
R7150		 Nezvalová-Henriksen (Control unexposed, disease free), 2013 Gestational age < 37 weeks during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 0.85 [0.61;1.17]
excluded (control group) 		41/575   13,013/178,565 13,054 575
ref
S3582
R7168		 Nezvalová-Henriksen (Control unexposed, sick), 2013 Gestational age < 37 weeks during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 0.60 [0.38;0.95] C 41/575   41/364 82 575
ref
S3531
R6977		 Olesen (Control unexposed, disease free), 2000 Preterm delivery (< 37 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 3.30 [1.30;8.50]
excluded (control group) 		5/34   950/15,995 955 34
ref
S3530
R6975		 Olesen (Control unexposed, sick), 2000 Preterm delivery (< 37 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 6.30 [1.20;32.00] 5/34   3/89 8 34
ref
S3490
R6736		 Shuhaiber (Control exposed to other treatments), 1998 Gestational age < 37 during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.50 [0.20;1.24] C
excluded (control group) 		8/82   16/90 24 82
ref
S3491
R6740		 Shuhaiber (Control unexposed, disease free), 1998 Gestational age < 37 during pregnancy (anytime or not specified) prospective cohort unexposed, disease free Adjustment: No 1.86 [0.58;5.93] C 8/82   5/91 13 82
ref
Total 3 studies 1.60 [0.43;5.97] 103 691
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nezvalová-Henriksen (Control unexposed, sick), 2013Nezvalová-Henriksen, 2013 1 0.60[0.38; 0.95]8257541%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Olesen (Control unexposed, sick), 2000Olesen, 2000 2 6.30[1.20; 32.00]83426%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Shuhaiber (Control unexposed, disease free), 1998Shuhaiber, 1998 3 1.86[0.58; 5.93]138233%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 79% 1.60[0.43; 5.97]1036910.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick; 2: Control unexposed, sick; 3: Control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.60[0.43; 5.97]10369179%NANezvalová-Henriksen (Control unexposed, sick), 2013 Olesen (Control unexposed, sick), 2000 Shuhaiber (Control unexposed, disease free), 1998 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.86[0.58; 5.93]1382 -NAShuhaiber (Control unexposed, disease free), 1998 1 unexposed, sickunexposed, sick 1.70[0.17; 16.63]9060986%NANezvalová-Henriksen (Control unexposed, sick), 2013 Olesen (Control unexposed, sick), 2000 2 Tags Adjustment   - No  - No 0.93[0.32; 2.71]9565768%NANezvalová-Henriksen (Control unexposed, sick), 2013 Shuhaiber (Control unexposed, disease free), 1998 2   - Yes  - Yes 6.30[1.22; 32.53]834 -NAOlesen (Control unexposed, sick), 2000 1 All studiesAll studies 1.60[0.43; 5.97]10369179%NANezvalová-Henriksen (Control unexposed, sick), 2013 Olesen (Control unexposed, sick), 2000 Shuhaiber (Control unexposed, disease free), 1998 30.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3490, 3531, 3581

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.59[0.63; 4.01]14,02269176%NANezvalová-Henriksen (Control unexposed, disease free), 2013 Olesen (Control unexposed, disease free), 2000 Shuhaiber (Control unexposed, disease free), 1998 3 unexposed, sick controlsunexposed, sick controls 1.70[0.17; 16.63]9060986%NANezvalová-Henriksen (Control unexposed, sick), 2013 Olesen (Control unexposed, sick), 2000 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.50[0.20; 1.24]2482 -NAShuhaiber (Control exposed to other treatments), 1998 10.510.01.0