Naratriptan

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3553
R7064		 Yusuf (Control exposed to Sumatriptan), 2018 Stillbirth (NOS) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 0.63 [0.04;10.66] C 0/190   14/3,496 14 190
ref
S3489
R6728		 Ephross (Naratriptan versus Sumatriptan), 2014 Fetal death (≥20 weeks of gestation) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.05;18.29] C 0/57   5/626 5 57
ref
Total 2 studies 0.79 [0.10;5.99] 19 247
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yusuf (Control exposed to Sumatriptan), 2018Yusuf, 2018 1 0.63[0.04; 10.66]1419051%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ephross (Naratriptan versus Sumatriptan), 2014Ephross, 2014 2 1.00[0.05; 18.29]55749%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.79[0.10; 5.99]192470.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control exposed to Sumatriptan; 2: Naratriptan versus Sumatriptan;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.79[0.10; 5.99]192470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.79[0.10; 5.99]192470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 Tags Adjustment   - No  - No 0.79[0.10; 5.99]192470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 All studiesAll studies 0.79[0.10; 5.99]192470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.79[0.10; 5.99]192470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 20.510.01.0