Rizatriptan

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3583
R7181		 Nezvalová-Henriksen (Control unexposed, disease free), 2013 Congenital malformations (major) 1st trimester population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.03 [0.55;1.93]
excluded (control group) 		10/310   5,292/178,565 5,302 310
ref
S3584
R7198		 Nezvalová-Henriksen (Control unexposed, sick), 2013 Congenital malformations (major) 1st trimester population based cohort retrospective unexposed, sick Adjustment: No 0.72 [0.31;1.69] C 10/310   12/271 22 310
ref
Total 1 studies 0.72 [0.31;1.69] 22 310
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nezvalová-Henriksen (Control unexposed, sick), 2013Nezvalová-Henriksen, 2013 1 0.72[0.31; 1.69]223100%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.72[0.31; 1.69]22310 -NANezvalová-Henriksen (Control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.72[0.31; 1.69]22310 -NANezvalová-Henriksen (Control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 0.72[0.31; 1.69]22310 -NANezvalová-Henriksen (Control unexposed, sick), 2013 1 All studiesAll studies 0.72[0.31; 1.69]22310 -NANezvalová-Henriksen (Control unexposed, sick), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3583

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.55; 1.93]5,302310 -NANezvalová-Henriksen (Control unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 0.72[0.31; 1.69]22310 -NANezvalová-Henriksen (Control unexposed, sick), 2013 10.510.01.0