Almotriptan

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3506
R6844		 Källén (control exposed to ergots), 2011 Any congenital malformations 1st trimester population based cohort propective exposed to other treatment, sick excluded Adjustment: No 4.82 [0.54;43.10] C
excluded (control group) 		1/6   21/527 22 6
ref
S3499
R6824		 Källén (control unexposed, disease free), 2011 Any congenital malformations 1st trimester population based cohort propective unexposed, disease free Adjustment: No 4.13 [0.48;35.38] C 1/6   56,759/1,229,901 56,760 6
ref
Total 1 studies 4.13 [0.48;35.38] 56,760 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källén (control unexposed, disease free), 2011Källén, 2011 1 4.13[0.48; 35.38]56,76060%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.13[0.48; 35.38]56,7606 -NAKällén (control unexposed, disease free), 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.13[0.48; 35.38]56,7606 -NAKällén (control unexposed, disease free), 2011 1 Tags Adjustment   - No  - No 4.13[0.48; 35.38]56,7606 -NAKällén (control unexposed, disease free), 2011 1 All studiesAll studies 4.13[0.48; 35.38]56,7606 -NAKällén (control unexposed, disease free), 2011 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3506

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.13[0.48; 35.38]56,7606 -NAKällén (control unexposed, disease free), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.82[0.54; 43.10]226 -NAKällén (control exposed to ergots), 2011 10.510.01.0