Eletriptan

All congenital malformations (majors, minors, majors and minors, or unspecified)

id	Study   Auto Spielmann (Control mainly exposed other treatments, sick), 2017Spielmann (Control unexposed, disease free), 2017Nezvalová-Henriksen (Control unexposed, disease free), 2013Nezvalová-Henriksen (Control unexposed, sick), 2013Källén (control exposed to ergots), 2011Källén (control unexposed, disease free), 2011	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3527 R11382	Spielmann (Control mainly exposed other treatments, sick), 2017	Major birth defects	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	2.04 [0.25;16.64] C excluded (control group)	1/18   12/429	13	18		ref
S3528 R11383	Spielmann (Control unexposed, disease free), 2017	Major birth defects	during pregnancy (anytime or not specified) excluded	prospective cohort	unexposed, disease free	Adjustment: No	1.98 [0.26;15.22] C excluded (exposition period)	1/18   44/1,526	45	18		ref
S3587 R7218	Nezvalová-Henriksen (Control unexposed, disease free), 2013	Congenital malformations (any)	1st trimester	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	0.79 [0.39;1.60] excluded (control group)	8/189   9,136/178,565	9,144	189		ref
S3588 R7235	Nezvalová-Henriksen (Control unexposed, sick), 2013	Congenital malformations (any)	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: No	0.51 [0.21;1.24] C	8/189   14/174	22	189		ref
S3507 R6848	Källén (control exposed to ergots), 2011	Any congenital malformations	1st trimester	population based cohort propective	exposed to other treatment, sick excluded	Adjustment: No	6.57 [1.70;25.33] C excluded (control group)	3/14   21/527	24	14		ref
S3500 R6825	Källén (control unexposed, disease free), 2011	Any congenital malformations	1st trimester	population based cohort propective	unexposed, disease free	Adjustment: No	5.17 [1.07;15.10]	3/14   56,759/1,229,901	56,762	14		ref
					Total	2 studies	1.53 [0.16;14.93]		56,784	203
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3507, 3587, 3527