Interferon beta (IFN-beta)

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3632
R7437		 Fragoso a (control exposed to Glatiramer), 2013 Gestational diabetes mellitus during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 0.32 [0.01;8.22] C 0/39   1/39 1 39
ref
S3636
R7511		 Fragoso b (control exposed to Glatiramer), 2013 Gestational diabetes at least 1st trimester retrospective cohort exposed to other treatment, sick Adjustment: No 0.80 [0.03;20.62] C 0/17   1/41 1 17
ref
Total 2 studies 0.51 [0.05;5.02] 2 56
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso a (control exposed to Glatiramer), 2013Fragoso a, 2013 1 0.32[0.01; 8.22]13950%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Fragoso b (control exposed to Glatiramer), 2013Fragoso b, 2013 2 0.80[0.03; 20.62]11750%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.51[0.05; 5.02]2560.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to Glatiramer; 2: control exposed to Glatiramer;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.51[0.05; 5.02]2560%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.51[0.05; 5.02]2560%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 2 Tags Adjustment   - No  - No 0.51[0.05; 5.02]2560%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 2 All studiesAll studies 0.51[0.05; 5.02]2560%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.51[0.05; 5.02]2560%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 20.510.01.0