Interferon beta (IFN-beta)

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3627
R7395		 Lu (control exposed to Glatiramer), 2012 Assisted vaginal delivery (forceps and/or vacuum use) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.67 [0.08;5.68] C
excluded (control group) 		3/12   2/6 5 12
ref
S3629
R7401		 Lu (control unexposed, sick), 2012 Assisted vaginal delivery (forceps and/or vacuum use) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 2.45 [0.63;9.53] C 3/12   33/276 36 12
ref
Total 1 studies 2.45 [0.63;9.53] 36 12
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lu (control unexposed, sick), 2012Lu, 2012 1 2.45[0.63; 9.53]36120%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.45[0.63; 9.53]3612 -NALu (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.45[0.63; 9.53]3612 -NALu (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 2.45[0.63; 9.53]3612 -NALu (control unexposed, sick), 2012 1 All studiesAll studies 2.45[0.63; 9.53]3612 -NALu (control unexposed, sick), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3627

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.45[0.63; 9.53]3612 -NALu (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.67[0.08; 5.68]512 -NALu (control exposed to Glatiramer), 2012 10.510.01.0