Interferon beta (IFN-beta)

Jaundice / Icterus

id	Study   Auto Fragoso a (control exposed to Glatiramer), 2013Fragoso a (control unexposed, sick), 2013Fragoso b (control exposed to Glatiramer), 2013Fragoso b (control unexposed, sick), 2013Finkelsztejn (control exposed to Glatiramer), 2011Finkelsztejn (control unexposed, sick), 2011	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3632 R7470	Fragoso a (control exposed to Glatiramer), 2013	Neonatal jaundice	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.54 [0.24;9.78] C excluded (control group)	3/39   2/39	5	39		ref
S3633 R7471	Fragoso a (control unexposed, sick), 2013	Neonatal jaundice	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	0.91 [0.23;3.61] C	3/39   8/95	11	39		ref
S3636 R7518	Fragoso b (control exposed to Glatiramer), 2013	Neonatal jaundice	at least 1st trimester	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	5.33 [0.45;63.23] C excluded (control group)	2/17   1/41	3	17		ref
S3637 R7535	Fragoso b (control unexposed, sick), 2013	Neonatal jaundice	at least 1st trimester	retrospective cohort	unexposed, sick	Adjustment: No	3.82 [0.59;24.83] C	2/17   3/89	5	17		ref
S3618 R7376	Finkelsztejn (control exposed to Glatiramer), 2011	Neonatal jaundice	early pregnancy	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.47 [0.07;31.84] C excluded (control group)	2/69   0/20	2	69		ref
S3619 R7378	Finkelsztejn (control unexposed, sick), 2011	Neonatal jaundice	early pregnancy	retrospective cohort	unexposed, sick	Adjustment: No	1.25 [0.11;14.26] C	2/69   1/43	3	69		ref
					Total	3 studies	1.46 [0.53;4.01]		19	125
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3618, 3632, 3636