Interferon beta (IFN-beta)

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3632
R53848		 Fragoso a (control exposed to Glatiramer), 2013 Late global neuropsychological and motor development - At mean age of 6.6 ± 6.9 years (range 1–39 years) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 3.08 [0.12;78.03] C
excluded (control group) 		1/39   0/39 1 39
ref
S3633
R53849		 Fragoso a (control unexposed, sick), 2013 Late global neuropsychological and motor development - At mean age of 6.6 ± 6.9 years (range 1–39 years) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.22 [0.11;13.90] C 1/39   2/95 3 39
ref
Total 1 studies 1.22 [0.11;13.90] 3 39
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso a (control unexposed, sick), 2013Fragoso a, 2013 1 1.22[0.11; 13.90]3390%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.11; 13.90]339 -NAFragoso a (control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.22[0.11; 13.90]339 -NAFragoso a (control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 1.22[0.11; 13.90]339 -NAFragoso a (control unexposed, sick), 2013 1 All studiesAll studies 1.22[0.11; 13.90]339 -NAFragoso a (control unexposed, sick), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3632

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.22[0.11; 13.90]339 -NAFragoso a (control unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.08[0.12; 78.03]139 -NAFragoso a (control exposed to Glatiramer), 2013 10.510.01.0