Interferon beta (IFN-beta)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3636
R7517		 Fragoso b (control exposed to Glatiramer), 2013 Low birth weight (<2500 g) at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 3.85 [0.89;16.72] C
excluded (control group) 		5/17   4/41 9 17
ref
S3637
R7534		 Fragoso b (control unexposed, sick), 2013 Low birth weight (<2500 g) at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 5.76 [1.52;21.84] C 5/17   6/89 11 17
ref
Total 1 studies 5.76 [1.52;21.84] 11 17
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso b (control unexposed, sick), 2013Fragoso b, 2013 1 5.76[1.52; 21.84]11170%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.76[1.52; 21.84]1117 -NAFragoso b (control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 5.76[1.52; 21.84]1117 -NAFragoso b (control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 5.76[1.52; 21.84]1117 -NAFragoso b (control unexposed, sick), 2013 1 All studiesAll studies 5.76[1.52; 21.84]1117 -NAFragoso b (control unexposed, sick), 2013 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3636

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 5.76[1.52; 21.84]1117 -NAFragoso b (control unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.85[0.89; 16.72]917 -NAFragoso b (control exposed to Glatiramer), 2013 10.510.01.0