Interferon beta (IFN-beta) updated on 07-06-2020

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3636
R7521		 Fragoso b (control exposed to Glatiramer), 2013 Neonatal complications at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.89 [0.84;9.95] C
excluded (control group) 		7/17   8/41 15 17
ref
S3637
R7538		 Fragoso b (control unexposed, sick), 2013 Neonatal complications at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 5.53 [1.72;17.79] C 7/17   10/89 17 17
ref
Total 1 studies 5.53 [1.72;17.79] 17 17
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso b (control unexposed, sick), 2013Fragoso b, 2013 1 5.53[1.72; 17.79]17170%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.53[1.72; 17.79]1717 -NAFragoso b (control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 5.53[1.72; 17.79]1717 -NAFragoso b (control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 5.53[1.72; 17.79]1717 -NAFragoso b (control unexposed, sick), 2013 1 All studiesAll studies 5.53[1.72; 17.79]1717 -NAFragoso b (control unexposed, sick), 2013 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3636

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 5.53[1.72; 17.79]1717 -NAFragoso b (control unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.89[0.84; 9.95]1517 -NAFragoso b (control exposed to Glatiramer), 2013 10.510.01.0