Fingolimod

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4889
R12888		 Pauliat, 2020 Spontaneous abortion (< 20th week of gestation) 1st trimester prospective cohort exposed to other treatment, sick Adjustment: Yes Matched 0.64 [0.22;1.81] 7/63   11/62 18 63
ref
S3803
R8116		 Karlsson (control exposed to IFN), 2014 Spontaneous abortion 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.29 [0.06;27.07] C
excluded (control group) 		9/61   0/4 9 61
ref
S3802
R8113		 Karlsson (control unexposed, sick), 2014 Spontaneous abortion 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.73 [0.20;15.22] C 9/61   1/11 10 61
ref
Total 2 studies 0.77 [0.30;2.00] 28 124
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pauliat, 2020Pauliat, 2020 0.64[0.22; 1.81]186381%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Karlsson (control unexposed, sick), 2014Karlsson, 2014 1 1.73[0.20; 15.22]106119%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.77[0.30; 2.00]281240.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.77[0.30; 2.00]281240%NAPauliat, 2020 Karlsson (control unexposed, sick), 2014 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.73[0.20; 15.22]1061 -NAKarlsson (control unexposed, sick), 2014 1 exposed to other treatment, sickexposed to other treatment, sick 0.64[0.22; 1.84]1863 -NAPauliat, 2020 1 Tags Adjustment   - No  - No 1.73[0.20; 15.22]1061 -NAKarlsson (control unexposed, sick), 2014 1   - Yes  - Yes 0.64[0.22; 1.84]1863 -NAPauliat, 2020 1 MatchedMatched 0.64[0.22; 1.84]1863 -NAPauliat, 2020 1 All studiesAll studies 0.77[0.30; 2.00]281240%NAPauliat, 2020 Karlsson (control unexposed, sick), 2014 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3803

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.73[0.20; 15.22]1061 -NAKarlsson (control unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.69[0.25; 1.87]271240%NAPauliat, 2020 Karlsson (control exposed to IFN), 2014 20.510.01.0