Fingolimod

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4889
R12889		 Pauliat, 2020 Pregnancy terminations 1st trimester prospective cohort exposed to other treatment, sick Adjustment: Yes Matched 1.88 [0.72;4.94] 15/63   6/62 21 63
ref
S3660
R7609		 Nguyen (control exposed to IFN), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.43 [0.18;11.73] C
excluded (control group) 		1/12   18/302 19 12
ref
S3661
R7612		 Nguyen (control unexposed, sick), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.48 [0.31;19.89] C 1/12   27/763 28 12
ref
S3803
R8117		 Karlsson (control exposed to IFN), 2014 Elective abortions 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.65 [0.09;4.92] C
excluded (control group) 		24/61   2/4 26 61
ref
S3802
R8114		 Karlsson (control unexposed, sick), 2014 Elective abortions 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.14 [0.03;0.73] C 24/61   9/11 33 61
ref
Total 3 studies 0.88 [0.16;4.97] 82 136
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pauliat, 2020Pauliat, 2020 1.88[0.72; 4.94]216340%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 2.48[0.31; 19.89]281227%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Karlsson (control unexposed, sick), 2014Karlsson, 2014 2 0.14[0.03; 0.73]336133%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 75% 0.88[0.16; 4.97]821360.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.16; 4.97]8213675%NAPauliat, 2020 Nguyen (control unexposed, sick), 2019 Karlsson (control unexposed, sick), 2014 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.55[0.03; 8.93]617378%NANguyen (control unexposed, sick), 2019 Karlsson (control unexposed, sick), 2014 2 exposed to other treatment, sickexposed to other treatment, sick 1.88[0.72; 4.92]2163 -NAPauliat, 2020 1 Tags Adjustment   - No  - No 0.55[0.03; 8.93]617378%NANguyen (control unexposed, sick), 2019 Karlsson (control unexposed, sick), 2014 2   - Yes  - Yes 1.88[0.72; 4.92]2163 -NAPauliat, 2020 1 MatchedMatched 1.88[0.72; 4.92]2163 -NAPauliat, 2020 1 All studiesAll studies 0.88[0.16; 4.97]8213675%NAPauliat, 2020 Nguyen (control unexposed, sick), 2019 Karlsson (control unexposed, sick), 2014 30.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3803, 3660

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.55[0.03; 8.93]617378%NANguyen (control unexposed, sick), 2019 Karlsson (control unexposed, sick), 2014 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.53[0.68; 3.41]661360%NAPauliat, 2020 Nguyen (control exposed to IFN), 2019 Karlsson (control exposed to IFN), 2014 30.510.01.0