Fingolimod

Preterm (< 37 weeks)

id	Study   Auto Pauliat, 2020Nguyen (control exposed to IFN), 2019Nguyen (control unexposed, sick), 2019	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S4889 R12891	Pauliat, 2020	Preterm (< 37 week)	1st trimester	prospective cohort	exposed to other treatment, sick	Adjustment: No Matched	1.52 [0.32;7.24] C	4/40   3/44	7	40		ref
S3660 R7607	Nguyen (control exposed to IFN), 2019	Pre-term (<37 weeks)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.59 [0.40;6.33] C excluded (control group)	3/10   57/268	60	10		ref
S3661 R7610	Nguyen (control unexposed, sick), 2019	Pre-term (<37 weeks)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	1.19 [0.30;4.64] C	3/10   182/686	185	10		ref
					Total	2 studies	1.32 [0.47;3.69]		192	50
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3660