Dimethyl fumarate

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3658
R7602		 Nguyen (control exposed to IFN), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 4.88 [1.24;19.23] C
excluded (control group) 		3/14   16/302 19 14
ref
S3659
R7605		 Nguyen (control unexposed, sick), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 3.89 [1.05;14.39] C 3/14   50/763 53 14
ref
S3783
R8088		 Gold, 2015 Spontaneous abortion (NOS) and Elective termination during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.13 [0.29;4.35] C 13/39   4/13 17 39
ref
Total 2 studies 2.12 [0.63;7.14] 70 53
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 3.89[1.05; 14.39]531451%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Gold, 2015Gold, 2015 1.13[0.29; 4.35]173949%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 40% 2.12[0.63; 7.14]70530.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.12[0.63; 7.14]705340%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.12[0.63; 7.14]705340%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 Tags Adjustment   - No  - No 2.12[0.63; 7.14]705340%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 All studiesAll studies 2.12[0.63; 7.14]705340%NANguyen (control unexposed, sick), 2019 Gold, 2015 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3658

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.12[0.63; 7.14]705340%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.88[1.24; 19.23]1914 -NANguyen (control exposed to IFN), 2019 10.510.01.0