Dimethyl fumarate

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3658
R7603		 Nguyen (control exposed to IFN), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.57 [0.03;9.93] C
excluded (control group) 		0/14   18/302 18 14
ref
S3659
R7606		 Nguyen (control unexposed, sick), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.99 [0.06;17.10] C 0/14   27/763 27 14
ref
S3783
R8087		 Gold, 2015 Elective terminations during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.90 [0.36;10.07] C 10/39   2/13 12 39
ref
Total 2 studies 1.61 [0.38;6.78] 39 53
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 0.99[0.06; 17.10]271426%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Gold, 2015Gold, 2015 1.90[0.36; 10.07]123974%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.61[0.38; 6.78]39530.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.61[0.38; 6.78]39530%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.61[0.38; 6.78]39530%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 Tags Adjustment   - No  - No 1.61[0.38; 6.78]39530%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 All studiesAll studies 1.61[0.38; 6.78]39530%NANguyen (control unexposed, sick), 2019 Gold, 2015 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3658

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.61[0.38; 6.78]39530%NANguyen (control unexposed, sick), 2019 Gold, 2015 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.57[0.03; 9.93]1814 -NANguyen (control exposed to IFN), 2019 10.510.01.0