Dimethyl fumarate

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3658
R7601		 Nguyen (control exposed to IFN), 2019 Pre-term (<37 weeks) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.39 [0.36;5.40] C
excluded (control group) 		3/11   57/268 60 11
ref
S3659
R7604		 Nguyen (control unexposed, sick), 2019 Pre-term (<37 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.04 [0.27;3.96] C 3/11   182/686 185 11
ref
Total 1 studies 1.04 [0.27;3.96] 185 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 1.04[0.27; 3.96]185110%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.04[0.27; 3.96]18511 -NANguyen (control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.04[0.27; 3.96]18511 -NANguyen (control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 1.04[0.27; 3.96]18511 -NANguyen (control unexposed, sick), 2019 1 All studiesAll studies 1.04[0.27; 3.96]18511 -NANguyen (control unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3658

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.04[0.27; 3.96]18511 -NANguyen (control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.39[0.36; 5.40]6011 -NANguyen (control exposed to IFN), 2019 10.510.01.0