Interferon beta 1a (IFN-beta1a)

Child/Infant infections (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3709
R7931		 Fragoso a (control exposed to Glatiramer), 2013 Infections (ear, throat, urinary, sinus) (> 1 year) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 7.92 [0.87;71.95] C
excluded (control group) 		5/29   1/39 6 29
ref
S3711
R7969		 Fragoso a (control unexposed, sick), 2013 Infections (ear, throat, urinary, sinus) (> 1 year) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 3.75 [1.00;14.02] C 5/29   5/95 10 29
ref
Total 1 studies 3.75 [1.00;14.02] 10 29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso a (control unexposed, sick), 2013Fragoso a, 2013 1 3.75[1.00; 14.02]10290%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.75[1.00; 14.02]1029 -NAFragoso a (control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.75[1.00; 14.02]1029 -NAFragoso a (control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 3.75[1.00; 14.02]1029 -NAFragoso a (control unexposed, sick), 2013 1 All studiesAll studies 3.75[1.00; 14.02]1029 -NAFragoso a (control unexposed, sick), 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3709

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.75[1.00; 14.02]1029 -NAFragoso a (control unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 7.92[0.87; 71.95]629 -NAFragoso a (control exposed to Glatiramer), 2013 10.510.01.0