Interferon beta 1a (IFN-beta1a) - Medication and Pregnancy KB

Interferon beta 1a (IFN-beta1a)

Major congenital malformations

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3698 R7881	Weber-Schoendorfer (control exposed to Glatiramer), 2009	Birth defects (major)	at least 1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	0.12 [0.01;2.59] ^C excluded (control group)	0/40 2/26	2	40		ref
S3700 R7889	Weber-Schoendorfer (control unexposed, disease free), 2009	Birth defects (major)	at least 1st trimester	prospective cohort	unexposed, disease free excluded	Adjustment: No	0.74 [0.04;12.47] ^C excluded (control group)	0/40 23/1,405	23	40		ref
S3702 R7897	Weber-Schoendorfer (control unexposed, sick), 2009	Birth defects (major)	at least 1st trimester	prospective cohort	unexposed, sick	Adjustment: No	0.19 [0.01;3.85] ^C	0/40 3/57	3	40		ref
					Total	1 studies	0.19 [0.01;3.85]		3	40
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: control unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3698, 3700