Interferon beta 1a (IFN-beta1a)

Preterm (< 37 weeks)

id	Study   Auto Nguyen (control exposed to Glatiramer), 2019Nguyen (control unexposed, sick), 2019Fragoso a (control exposed to Glatiramer), 2013Fragoso a (control unexposed, sick), 2013Weber-Schoendorfer (control exposed to Glatiramer), 2009Weber-Schoendorfer (control unexposed, disease free), 2009Weber-Schoendorfer (control unexposed, sick), 2009	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3705 R7905	Nguyen (control exposed to Glatiramer), 2019	Pre-term (<37 weeks)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	0.80 [0.46;1.41] C excluded (control group)	47/223   24/96	71	223		ref
S3707 R7911	Nguyen (control unexposed, sick), 2019	Pre-term (<37 weeks)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	0.74 [0.51;1.06] C	47/223   182/686	229	223		ref
S3709 R7919	Fragoso a (control exposed to Glatiramer), 2013	Prematurity (NOS)	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	6.08 [0.64;57.61] C excluded (control group)	4/29   1/39	5	29		ref
S3711 R7957	Fragoso a (control unexposed, sick), 2013	Prematurity (NOS)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	4.91 [1.03;23.37] C	4/29   3/95	7	29		ref
S3698 R7879	Weber-Schoendorfer (control exposed to Glatiramer), 2009	Preterm births	at least 1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	3.43 [0.38;31.22] C excluded (control group)	5/40   1/25	6	40		ref
S3700 R7887	Weber-Schoendorfer (control unexposed, disease free), 2009	Preterm births	at least 1st trimester	prospective cohort	unexposed, disease free excluded	Adjustment: No	2.04 [0.78;5.34] C excluded (control group)	5/40   90/1,377	95	40		ref
S3702 R7895	Weber-Schoendorfer (control unexposed, sick), 2009	Preterm births	at least 1st trimester	prospective cohort	unexposed, sick	Adjustment: No	0.84 [0.25;2.79] C	5/40   8/55	13	40		ref
					Total	3 studies	1.16 [0.45;2.99]		249	292
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3698, 3700, 3709, 3705