Interferon beta 1b (IFN-beta1b)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3737
R8030		 Colvin, 2010 Birth defects 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 3.40 [0.40;28.00] 1/7   4,994/106,067 4,995 7
ref
S3699
R7885		 Weber-Schoendorfer (control exposed to Glatiramer), 2009 Birth defects (major) at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.35 [0.02;7.80] C
excluded (control group) 		0/14   2/26 2 14
ref
S3701
R7893		 Weber-Schoendorfer (control unexposed, disease free), 2009 Birth defects (major) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 2.18 [0.13;37.72] C
excluded (control group) 		0/14   23/1,405 23 14
ref
S3703
R7901		 Weber-Schoendorfer (control unexposed, sick), 2009 Birth defects (major) at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.57 [0.03;11.63] C 0/14   3/57 3 14
ref
Total 2 studies 1.88 [0.33;10.69] 4,998 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2010Colvin, 2010 3.40[0.40; 28.00]4,995767%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Weber-Schoendorfer (control unexposed, sick), 2009Weber-Schoendorfer, 2009 1 0.57[0.03; 11.63]31433%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.88[0.33; 10.69]4,998210.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.88[0.33; 10.69]4,998210%NAColvin, 2010 Weber-Schoendorfer (control unexposed, sick), 2009 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.40[0.41; 28.45]4,9957 -NAColvin, 2010 1 unexposed, sickunexposed, sick 0.57[0.03; 11.63]314 -NAWeber-Schoendorfer (control unexposed, sick), 2009 1 Tags Adjustment   - No  - No 1.88[0.33; 10.69]4,998210%NAColvin, 2010 Weber-Schoendorfer (control unexposed, sick), 2009 2 All studiesAll studies 1.88[0.33; 10.69]4,998210%NAColvin, 2010 Weber-Schoendorfer (control unexposed, sick), 2009 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3699, 3701

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.90[0.53; 15.93]5,018210%NAColvin, 2010 Weber-Schoendorfer (control unexposed, disease free), 2009 2 unexposed, sick controlsunexposed, sick controls 0.57[0.03; 11.63]314 -NAWeber-Schoendorfer (control unexposed, sick), 2009 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.35[0.02; 7.80]214 -NAWeber-Schoendorfer (control exposed to Glatiramer), 2009 10.510.01.0