Interferon beta 1b (IFN-beta1b)

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3706
R7910		 Nguyen (control exposed to Glatiramer), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.75 [0.45;6.81] C
excluded (control group) 		4/52   5/110 9 52
ref
S3708
R7916		 Nguyen (control unexposed, sick), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.27 [0.76;6.76] C 4/52   27/763 31 52
ref
Total 1 studies 2.27 [0.76;6.76] 31 52
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 2.27[0.76; 6.76]31520%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.27[0.76; 6.76]3152 -NANguyen (control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.27[0.76; 6.76]3152 -NANguyen (control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 2.27[0.76; 6.76]3152 -NANguyen (control unexposed, sick), 2019 1 All studiesAll studies 2.27[0.76; 6.76]3152 -NANguyen (control unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3706

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.27[0.76; 6.76]3152 -NANguyen (control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.75[0.45; 6.81]952 -NANguyen (control exposed to Glatiramer), 2019 10.510.01.0