Metronidazole (all routes except local only) updated on 01-29-2025

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17594
R74257		 Muanda a (Controls exposed to penicillins), 2017 Genital organs system 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 0.60 [0.15;2.46]
excluded (control group) 		2/412   75/9,106 77 412
ref
S17595
R74271		 Muanda a (Controls unexposed, NOS), 2017 Genital organs system 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.54 [0.13;2.18] 2/412   1,150/124,469 1,152 412
ref
Total 1 studies 0.54 [0.13;2.21] 1,152 412
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Muanda a (Controls unexposed, NOS), 2017Muanda a, 2017 1 0.54[0.13; 2.18]1,1524120%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.54[0.13; 2.21]1,152412 -NAMuanda a (Controls unexposed, NOS), 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.54[0.13; 2.21]1,152412 -NAMuanda a (Controls unexposed, NOS), 2017 1 Tags Adjustment   - Yes  - Yes 0.54[0.13; 2.21]1,152412 -NAMuanda a (Controls unexposed, NOS), 2017 1 All studiesAll studies 0.54[0.13; 2.21]1,152412 -NAMuanda a (Controls unexposed, NOS), 2017 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17594

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.54[0.13; 2.21]1,152412 -NAMuanda a (Controls unexposed, NOS), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.60[0.15; 2.43]77412 -NAMuanda a (Controls exposed to penicillins), 2017 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Ajiji (Genital organs system)Ajiji (Genital organs system) 1.06[0.68; 1.64]23%-Wwhatever (meta-analysis)T1+at least 1st trimesterstudies TTT4 metaPregmetaPreg 0.54[0.13; 2.21]NaN%412----Muanda a (Controls unexposed, NOS), 2017 10.510.01.0