Calcium channel blockers (versus unexposed)

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13969
R54758		 Parazzini - Nifedipine, 1998 Admission to neonatal care unit for intensive care 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.80 [0.70;4.60] 12/123   7/126 19 123
ref
S13986
R54918		 Wide-Swensson - Isradipine, 1995 Neonatal ward 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.06 [0.41;2.73] C 12/46   11/44 23 46
ref
Total 2 studies 1.38 [0.71;2.70] 42 169
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parazzini - Nifedipine, 1998Parazzini - Nifedipine, 1998 1.80[0.70; 4.60]1912350%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Wide-Swensson - Isradipine, 1995Wide-Swensson - Isradipine, 1995 1.06[0.41; 2.73]234650%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: lowROB reporting: moderate Total (2 studies) I2 = 0% 1.38[0.71; 2.70]421690.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.38[0.71; 2.70]421690%NAParazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 2 Type of controls unexposed, sickunexposed, sick 1.38[0.71; 2.70]421690%NAParazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 2 Tags Adjustment   - Randomisation  - Randomisation 1.38[0.71; 2.70]421690%NAParazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.38[0.71; 2.70]421690%NAParazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 2 All studiesAll studies 1.38[0.71; 2.70]421690%NAParazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.38[0.71; 2.70]421690%NAParazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Firoz (Nifedipine) (Admission to Neonatal int ...Firoz (Nifedipine) (Admission to Neonatal intensive care unit (versus Labetalol iv)) 1.00[0.18; 5.51]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT1 Abalos (Admission to neonatal or intensive ca ...Abalos (Admission to neonatal or intensive care nursery (RCT versus no antihypertensive drugs/placebo)) 1.18[0.87; 1.62]14%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT2 Bone - GESTATIONAL HYPERTENSION (Neonatal car ...Bone - GESTATIONAL HYPERTENSION (Neonatal care unit admission) 1.21[0.66; 2.27]27%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bone - GESTATIONAL HYPERTENSION (Neonatal car ...Bone - GESTATIONAL HYPERTENSION (Neonatal care unit admission (versus methyldopa)) 1.19[0.43; 3.52]37%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 George - Nifedipine (Neonatal fetal heart rat ...George - Nifedipine (Neonatal fetal heart rate abnormalities) 0.98[0.67; 1.43]0%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT7 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION (Neonatal intensive care unit (NICU) admission) 1.30[0.88; 1.96]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT5 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION (DUPLICATE) (Neonatal intensive care unit (NICU) admission) 1.30[0.88; 1.96]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT5 George - Nifedipine (Neonatal intensive care ...George - Nifedipine (Neonatal intensive care unit (NICU) admissions) 0.98[0.65; 1.47]38%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT11 Shi (Nifedipine) - GESTATIONAL HYPERTENSION ( ...Shi (Nifedipine) - GESTATIONAL HYPERTENSION (Neonatal Intensive Care Unit admission (versus intravenous labetalol)) 1.01[0.63; 1.62]0%-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT3 Liu - Nifedipine (Neonatal respiratory distre ...Liu - Nifedipine (Neonatal respiratory distress syndrome) 1.24[0.57; 2.67]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 1.38[0.71; 2.70]0%169----Parazzini - Nifedipine, 1998 Wide-Swensson - Isradipine, 1995 20.510.01.0