Calcium channel blockers (versus unexposed)

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13787
R54027
Fisher a - Calcium blockers, 2018 Cleft palate only 1st trimester case control unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.04 [0.24;4.57] C 2/16   1,439/11,879 1,441 16
ref
S13996
R54977
Sorensen - Calcium blockers, 2001 Cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.20 [0.20;9.00] 1/50   595/38,697 596 50
ref
Total 2 studies 1.10 [0.34;3.53] 2,037 66
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fisher a - Calcium blockers, 2018Fisher a - Calcium blockers, 2018 1.04[0.24; 4.57]1,4411662%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Sorensen - Calcium blockers, 2001Sorensen - Calcium blockers, 2001 1.20[0.20; 9.00]5965038%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.10[0.34; 3.53]2,037660.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.10[0.34; 3.53]2,037660%NAFisher a - Calcium blockers, 2018 Sorensen - Calcium blockers, 2001 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.10[0.34; 3.53]2,037660%NAFisher a - Calcium blockers, 2018 Sorensen - Calcium blockers, 2001 2 Tags Adjustment   - No  - No 1.04[0.24; 4.57]1,44116 -NAFisher a - Calcium blockers, 2018 1   - Yes  - Yes 1.20[0.18; 8.05]59650 -NASorensen - Calcium blockers, 2001 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.10[0.34; 3.53]2,037660%NAFisher a - Calcium blockers, 2018 Sorensen - Calcium blockers, 2001 2 All studiesAll studies 1.10[0.34; 3.53]2,037660%NAFisher a - Calcium blockers, 2018 Sorensen - Calcium blockers, 2001 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.34; 3.53]2,037660%NAFisher a - Calcium blockers, 2018 Sorensen - Calcium blockers, 2001 20.510.01.0