Calcium channel blockers (versus unexposed)

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13996
R54976		 Sorensen - Calcium blockers, 2001 Cleft lip with or without palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.20 [0.80;6.20] 4/53   1,364/39,466 1,368 53
ref
Total 1 studies 2.20 [0.79;6.12] 1,368 53
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sorensen - Calcium blockers, 2001Sorensen - Calcium blockers, 2001 2.20[0.80; 6.20]1,368530%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.20[0.79; 6.12]1,36853 -NASorensen - Calcium blockers, 2001 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.20[0.79; 6.12]1,36853 -NASorensen - Calcium blockers, 2001 1 Tags Adjustment   - Yes  - Yes 2.20[0.79; 6.12]1,36853 -NASorensen - Calcium blockers, 2001 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.20[0.79; 6.12]1,36853 -NASorensen - Calcium blockers, 2001 1 All studiesAll studies 2.20[0.79; 6.12]1,36853 -NASorensen - Calcium blockers, 2001 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.20[0.79; 6.12]1,36853 -NASorensen - Calcium blockers, 2001 10.510.01.0