Calcium channel blockers (versus unexposed) updated on 03-11-2025

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14252
R56036		 Fisher - Calcium blockers (Controls unexposed, disease free), 2017 Secundum atrial septal defect (ASD) early pregnancy case control unexposed, disease free excluded Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.41 [0.85;6.83]
excluded (control group) 		7/18   -/- - 18
ref
S14253
R56044		 Fisher - Calcium blockers (Controls unexposed, sick), 2017 Secundum atrial septal defect (ASD) early pregnancy case control unexposed, sick Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.18 [0.73;6.51] 7/18   -/- - 18
ref
Total 1 studies 2.18 [0.73;6.51] 0 18
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fisher - Calcium blockers (Controls unexposed, sick), 2017Fisher - Calcium blockers, 2017 1 2.18[0.73; 6.51]-180%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.18[0.73; 6.51]-18 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 Type of controls unexposed, sickunexposed, sick 2.18[0.73; 6.51]-18 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 Tags Adjustment   - Yes  - Yes 2.18[0.73; 6.51]-18 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.18[0.73; 6.51]-18 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 All studiesAll studies 2.18[0.73; 6.51]-18 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14252

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.41[0.85; 6.83]-18 -NAFisher - Calcium blockers (Controls unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 2.18[0.73; 6.51]-18 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 10.510.01.0