Calcium channel blockers (versus unexposed)

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13828
R54190		 Van Zutphen - Calcium blockers, 2014 Severe hypospadias (ie, subcoronal or penile, scrotal, or perineal meatal opening) early pregnancy case control unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.07 [0.28;4.05] 4/11   2,127/7,249 2,131 11
ref
S13996
R54987		 Sorensen - Calcium blockers, 2001 Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.40 [0.60;3.60] 5/54   3,027/41,129 3,032 54
ref
Total 2 studies 1.29 [0.61;2.71] 5,163 65
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van Zutphen - Calcium blockers, 2014Van Zutphen - Calcium blockers, 2014 1.07[0.28; 4.05]2,1311131%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Sorensen - Calcium blockers, 2001Sorensen - Calcium blockers, 2001 1.40[0.60; 3.60]3,0325469%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.29[0.61; 2.71]5,163650.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.29[0.61; 2.71]5,163650%NAVan Zutphen - Calcium blockers, 2014 Sorensen - Calcium blockers, 2001 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.29[0.61; 2.71]5,163650%NAVan Zutphen - Calcium blockers, 2014 Sorensen - Calcium blockers, 2001 2 Tags Adjustment   - Yes  - Yes 1.29[0.61; 2.71]5,163650%NAVan Zutphen - Calcium blockers, 2014 Sorensen - Calcium blockers, 2001 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.29[0.61; 2.71]5,163650%NAVan Zutphen - Calcium blockers, 2014 Sorensen - Calcium blockers, 2001 2 All studiesAll studies 1.29[0.61; 2.71]5,163650%NAVan Zutphen - Calcium blockers, 2014 Sorensen - Calcium blockers, 2001 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.29[0.61; 2.71]5,163650%NAVan Zutphen - Calcium blockers, 2014 Sorensen - Calcium blockers, 2001 20.510.01.0