Calcium channel blockers (versus unexposed)

Jaundice / Icterus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13988
R54967		 Magee - Calcium blockers, 1996 Jaundice at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 0.45 [0.10;2.02] C 4/14   8/17 12 14
ref
Total 1 studies 0.45 [0.10;2.02] 12 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Magee - Calcium blockers, 1996Magee - Calcium blockers, 1996 0.45[0.10; 2.02]12140%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 1 Tags Adjustment   - No  - No 0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 1 MatchedMatched 0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 1 All studiesAll studies 0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.45[0.10; 2.02]1214 -NAMagee - Calcium blockers, 1996 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Abalos (Neonatal jaundice (RCT versus no anti ...Abalos (Neonatal jaundice (RCT versus no antihypertensive drugs/placebo)) 0.62[0.35; 1.10]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg Out of scale0.45[0.10; 2.02]NaN%14----Magee - Calcium blockers, 1996 10.510.01.0