Calcium channel blockers (versus unexposed) - Medication and Pregnancy KB

Calcium channel blockers (versus unexposed)

Hypoplastic left heart (HLH/HLHS)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S14252 R56031	Fisher - Calcium blockers (Controls unexposed, disease free), 2017	Hypoplastic left heart syndrome	early pregnancy	case control	unexposed, disease free excluded	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified	5.00 [0.89;18.99] excluded (control group)	3/14 -/-	-	14		ref
S14253 R56039	Fisher - Calcium blockers (Controls unexposed, sick), 2017	Hypoplastic left heart syndrome	early pregnancy	case control	unexposed, sick	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified	5.21 [0.90;20.72]	3/14 -/-	-	14		ref
					Total	1 studies	5.21 [1.09;25.00]		0	14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14252