Calcium channel blockers (versus unexposed)

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14252
R56031
Fisher - Calcium blockers (Controls unexposed, disease free), 2017 Hypoplastic left heart syndrome early pregnancy case control unexposed, disease free excluded Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 5.00 [0.89;18.99]
excluded (control group)
3/14   -/- - 14
ref
S14253
R56039
Fisher - Calcium blockers (Controls unexposed, sick), 2017 Hypoplastic left heart syndrome early pregnancy case control unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 5.21 [0.90;20.72] 3/14   -/- - 14
ref
Total 1 studies 5.21 [1.09;25.00] 0 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fisher - Calcium blockers (Controls unexposed, sick), 2017Fisher - Calcium blockers, 2017 1 5.21[0.90; 20.72]-140%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 5.21[1.09; 25.00]-14 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 Type of controls unexposed, sickunexposed, sick 5.21[1.09; 25.00]-14 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 Tags Adjustment   - No  - No 5.21[1.09; 25.00]-14 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 5.21[1.09; 25.00]-14 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 1 All studiesAll studies 5.21[1.09; 25.00]-14 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14252

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.00[1.08; 23.10]-14 -NAFisher - Calcium blockers (Controls unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 5.21[1.09; 25.00]-14 -NAFisher - Calcium blockers (Controls unexposed, sick), 2017 10.510.01.0