Calcium channel blockers (versus unexposed)

Ebstein's anomaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13433
R51711		 Caton - Calcium blockers, 2009 Ebstein malformation 1st trimester case control unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 5.71 [0.32;102.47] C 0/6   65/4,855 65 6
ref
Total 1 studies 5.71 [0.32;102.47] 65 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Caton - Calcium blockers, 2009Caton - Calcium blockers, 2009 5.71[0.32; 102.47]6560%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 5.71[0.32; 102.47]656 -NACaton - Calcium blockers, 2009 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.71[0.32; 102.47]656 -NACaton - Calcium blockers, 2009 1 Tags Adjustment   - No  - No 5.71[0.32; 102.47]656 -NACaton - Calcium blockers, 2009 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 5.71[0.32; 102.47]656 -NACaton - Calcium blockers, 2009 1 All studiesAll studies 5.71[0.32; 102.47]656 -NACaton - Calcium blockers, 2009 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.71[0.32; 102.47]656 -NACaton - Calcium blockers, 2009 10.510.01.0