Calcium channel blockers (versus unexposed)

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13988
R54958		 Magee - Calcium blockers, 1996 Perinatal death at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 5.13 [0.24;108.52] C 2/81   0/81 2 81
ref
Total 1 studies 5.13 [0.24;108.52] 2 81
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Magee - Calcium blockers, 1996Magee - Calcium blockers, 1996 5.13[0.24; 108.52]2810%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 1 Tags Adjustment   - No  - No 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 1 MatchedMatched 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 1 All studiesAll studies 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.13[0.24; 108.52]281 -NAMagee - Calcium blockers, 1996 10.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period Bellos - NifedipineBellos - Nifedipine 0.71[0.34; 1.49]NA-unexposed, sickduring pregnancy (anytime or not specified)studies-9 Bellos - NifedipineBellos - Nifedipine 0.93[0.46; 1.86]NA-unexposed, sickduring pregnancy (anytime or not specified)studies-9 Bone - GESTATIONAL HYPERTENSIONBone - GESTATIONAL HYPERTENSION 0.82[0.21; 2.93]29%-unexposed, sickduring pregnancy (anytime or not specified)studies-9 Bone - GESTATIONAL HYPERTENSIONBone - GESTATIONAL HYPERTENSION 1.06[0.39; 2.79]30%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies-9 Bone - GESTATIONAL HYPERTENSIONBone - GESTATIONAL HYPERTENSION 1.38[0.65; 2.81]27%-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies-9 Liu - NifedipineLiu - Nifedipine Out of scale0.49[0.22; 1.11]NA-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies-9 metaPregmetaPreg 5.13[0.24; 108.52]NaN%81--Magee - Calcium blockers, 1996 10.510.01.0